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Autophagy. 2014 May;10(5):928-9. doi: 10.4161/auto.28236. Epub 2014 Feb 27.

Vacuolar cell death in plants: Metacaspase releases the brakes on autophagy.

Author information

1
Department of Plant Biology; Uppsala BioCenter; Swedish University of Agricultural Sciences and Linnean Centre for Plant Biology; Uppsala, Sweden.
2
Institute of Biological Chemistry; Washington State University; Pullman, WA USA; Institute of Global Food Security; Queen's University Belfast; Belfast, UK.

Abstract

Vacuolar programmed cell death (PCD) is indispensable for plant development and is accompanied by a dramatic growth of lytic vacuoles, which gradually digest cytoplasmic content leading to self-clearance of dying cells. Our recent data demonstrate that vacuolar PCD critically requires autophagy and its upstream regulator, a caspase-fold protease metacaspase. Furthermore, both components lie downstream of the point of no return in the cell-death pathway. Here we consider the possibilities that i) autophagy could have both cytotoxic and cytoprotective roles in the vacuolar PCD, and ii) metacaspase could augment autophagic flux through targeting an as yet unknown autophagy repressor.

KEYWORDS:

autophagy; embryo-suspensor; metacaspase; necrosis; plants; vacuolar cell death

PMID:
24589969
PMCID:
PMC5119062
DOI:
10.4161/auto.28236
[Indexed for MEDLINE]
Free PMC Article

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