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Items: 12


Changing Trends in Computational Drug Repositioning.

Yella JK, Yaddanapudi S, Wang Y, Jegga AG.

Pharmaceuticals (Basel). 2018 Jun 5;11(2). pii: E57. doi: 10.3390/ph11020057. Review.


Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model.

Munjal C, Jegga AG, Opoka AM, Stoilov I, Norris RA, Thomas CJ, Smith JM, Mecham RP, Bressan GM, Hinton RB.

Physiol Rep. 2017 Mar;5(5). pii: e13152. doi: 10.14814/phy2.13152.


Hsp90 regulation of fibroblast activation in pulmonary fibrosis.

Sontake V, Wang Y, Kasam RK, Sinner D, Reddy GB, Naren AP, McCormack FX, White ES, Jegga AG, Madala SK.

JCI Insight. 2017 Feb 23;2(4):e91454. doi: 10.1172/jci.insight.91454.


Pharmacogenomics and chemical library screens reveal a novel SCFSKP2 inhibitor that overcomes Bortezomib resistance in multiple myeloma.

Malek E, Abdel-Malek MA, Jagannathan S, Vad N, Karns R, Jegga AG, Broyl A, van Duin M, Sonneveld P, Cottini F, Anderson KC, Driscoll JJ.

Leukemia. 2017 Mar;31(3):645-653. doi: 10.1038/leu.2016.258. Epub 2016 Sep 28.


Data mining differential clinical outcomes associated with drug regimens using adverse event reporting data.

Sarangdhar M, Tabar S, Schmidt C, Kushwaha A, Shah K, Dahlquist JE, Jegga AG, Aronow BJ.

Nat Biotechnol. 2016 Jul 12;34(7):697-700. doi: 10.1038/nbt.3623. No abstract available.


Concept Modeling-based Drug Repositioning.

Patchala J, Jegga AG.

AMIA Jt Summits Transl Sci Proc. 2015 Mar 23;2015:222-6. eCollection 2015.


Pharmacological inhibition of apical sodium-dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice.

Miethke AG, Zhang W, Simmons J, Taylor AE, Shi T, Shanmukhappa SK, Karns R, White S, Jegga AG, Lages CS, Nkinin S, Keller BT, Setchell KD.

Hepatology. 2016 Feb;63(2):512-23. doi: 10.1002/hep.27973. Epub 2015 Aug 21.


Computational drug repositioning through heterogeneous network clustering.

Wu C, Gudivada RC, Aronow BJ, Jegga AG.

BMC Syst Biol. 2013;7 Suppl 5:S6. doi: 10.1186/1752-0509-7-S5-S6. Epub 2013 Dec 9.


Drug repositioning for orphan diseases.

Sardana D, Zhu C, Zhang M, Gudivada RC, Yang L, Jegga AG.

Brief Bioinform. 2011 Jul;12(4):346-56. doi: 10.1093/bib/bbr021. Epub 2011 Apr 18. Review.


Chemical-protein interactome and its application in off-target identification.

Yang L, Wang KJ, Wang LS, Jegga AG, Qin SY, He G, Chen J, Xiao Y, He L.

Interdiscip Sci. 2011 Mar;3(1):22-30. doi: 10.1007/s12539-011-0051-8. Epub 2011 Mar 3. Review.


Integrative systems biology approaches to identify and prioritize disease and drug candidate genes.

Kaimal V, Sardana D, Bardes EE, Gudivada RC, Chen J, Jegga AG.

Methods Mol Biol. 2011;700:241-59. doi: 10.1007/978-1-61737-954-3_16.


Inferring novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships.

Qu XA, Gudivada RC, Jegga AG, Neumann EK, Aronow BJ.

BMC Bioinformatics. 2009 May 6;10 Suppl 5:S4. doi: 10.1186/1471-2105-10-S5-S4.

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