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Depress Res Treat. 2014;2014:816524. doi: 10.1155/2014/816524. Epub 2014 Jan 2.

Personality pathology predicts outcomes in a treatment-seeking sample with bipolar I disorder.

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1
Alpert Medical School of Brown University and Butler Hospital, Psychosocial Research, 345 Blackstone Boulevard, Providence, RI, 02906, USA.

Abstract

We conducted a secondary analysis of data from a clinical trial to explore the relationship between degree of personality disorder (PD) pathology (i.e., number of subthreshold and threshold PD symptoms) and mood and functioning outcomes in Bipolar I Disorder (BD-I). Ninety-two participants completed baseline mood and functioning assessments and then underwent 4 months of treatment for an index manic, mixed, or depressed phase acute episode. Additional assessments occurred over a 28-month follow-up period. PD pathology did not predict psychosocial functioning or manic symptoms at 4 or 28 months. However, it did predict depressive symptoms at both timepoints, as well as percent time symptomatic. Clusters A and C pathology were most strongly associated with depression. Our findings fit with the literature highlighting the negative repercussions of PD pathology on a range of outcomes in mood disorders. This study builds upon previous research, which has largely focused on major depression and which has primarily taken a categorical approach to examining PD pathology in BD.

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