Immunologic studies of patients with chronic encephalitis induced by post-exposure Semple rabies vaccine

T Hemachudha; D E Griffin; R T Johnson; J J Giffels

doi:10.1212/wnl.38.1.42

Immunologic studies of patients with chronic encephalitis induced by post-exposure Semple rabies vaccine

Neurology. 1988 Jan;38(1):42-4. doi: 10.1212/wnl.38.1.42.

Authors

T Hemachudha¹, D E Griffin, R T Johnson, J J Giffels

Affiliation

¹ Department of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand.

PMID: 2447520
DOI: 10.1212/wnl.38.1.42

Abstract

Neurologic complications of brain tissue-derived rabies vaccine may be chronic or progressive. Lymphocytes and serum from three patients with this form of encephalitis were studied. Two patients had positive lymphoproliferation to purified myelin, two had antibody to white matter, and one had antibody to myelin basic protein. No patient had antibody to proteolipid protein, myelin-associated glycoprotein, or cerebroside.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Antibodies / analysis
Brain / immunology
Chronic Disease
Encephalitis / blood
Encephalitis / cerebrospinal fluid
Encephalitis / etiology*
Encephalitis / immunology
Enzyme-Linked Immunosorbent Assay
Humans
Myelin Basic Protein / blood
Myelin Basic Protein / cerebrospinal fluid
Rabies Vaccines / adverse effects*
Recurrence

Substances

Antibodies
Myelin Basic Protein
Rabies Vaccines