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Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1746-54. doi: 10.1002/anie.201304060. Epub 2014 Jan 20.

Integrated antimicrobial and nonfouling zwitterionic polymers.

Author information

1
Department of Chemical Engineering, University of Washington, Seattle, WA 98195 (USA).

Abstract

Zwitterionic polymers are generally viewed as a new class of nonfouling materials. Unlike their poly(ethylene glycol) (PEG) counterparts, zwitterionic polymers have a broader chemical diversity and greater freedom for molecular design. In this Minireview, we highlight recent microbiological applications of zwitterionic polymers and their derivatives, with an emphasis on several unique molecular strategies to integrate antimicrobial and nonfouling properties. We will also discuss our insights into the bacterial nonfouling performance of zwitterionic polymers and one example of engineering zwitterionic polymer derivatives for antimicrobial wound-dressing applications.

KEYWORDS:

antimicrobial; bactericidal; nonfouling; polymers; zwitterions

PMID:
24446141
DOI:
10.1002/anie.201304060
[Indexed for MEDLINE]

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