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Autophagy. 2014 Mar;10(3):520-1. doi: 10.4161/auto.27564. Epub 2014 Jan 7.

Signaling unmasked: Autophagy and catalase promote programmed cell death.

Author information

1
Department of Biology; University of Copenhagen; Copenhagen, Denmark.
2
Department of Plant Biology and Forest Genetics; Swedish University of Agricultural Sciences (SLU) and Linnean Center for Plant Biology; Uppsala BioCenter; Uppsala, Sweden.
3
Department of Molecular Biology and Genetics; Aarhus University; Aarhus, Denmark.

Abstract

Autophagy contributes to the removal of harmful cellular refuse, whereas catalase plays an important protective role by detoxifying reactive oxygen species. We recently found that autophagy and catalase are also required for promoting programmed cell death induced during plant immune responses. Here we discuss the difficulties in identifying cell death effectors, which are also required to maintain cellular homeostasis, and how their prodeath roles were unmasked using an unbiased forward genetics approach.

KEYWORDS:

autophagy; catalase; cell death; plant defense; plant-microbe interactions

PMID:
24412967
PMCID:
PMC4077890
DOI:
10.4161/auto.27564
[Indexed for MEDLINE]
Free PMC Article

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