1. Biomol Ther (Seoul). 2013 Nov;21(6):442-6. doi: 10.4062/biomolther.2013.073.

The Longevity Properties of 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose from Curcuma
longa in Caenorhabditis elegans.

Ahn D(1), Cha DS(1), Lee EB(1), Kim BJ(1), Lee SY(1), Jeon H(1), Ahn MS(2), Lim
HW(3), Lee HY(4), Kim DK(1).

Author information: 
(1)College of Pharmacy, Woosuk University, Jeonju 565-701.
(2)Jeollabuk-do Agricultural Research and Extension Servieces, Iksan 570-704.
(3)Bio Bldg, Chuncheon 200-160.
(4)Department of Food Science and Engineering, Seowon University, Cheongju
361-742, Republic of Korea.

Here in this study, we isolated 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) from 
Curcuma longa L. and elucidated the lifespanextending effect of PGG using
Caenorhabditis elegans model system. In the present study, PGG demonstrated
potent lifespan extension of worms under normal culture condition. Then, we
determined the protective effects of PGG on the stress conditions such as thermal
and oxidative stress. In the case of heat stress, PGG-treated worms exhibited
enhanced survival rate, compared to control worms. In addition, PGG-fed worms
lived longer than control worms under oxidative stress induced by paraquat. To
verify the possible mechanism of PGG-mediated increased lifespan and stress
resistance of worms, we investigated whether PGG might alter superoxide dismutase
(SOD) activities and intracellular ROS levels. Our results showed that PGG was
able to elevate SOD activities of worms and reduce intracellular ROS accumulation
in a dose-dependent manner.

DOI: 10.4062/biomolther.2013.073 
PMCID: PMC3879915
PMID: 24404334