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Bioorg Med Chem Lett. 2014 Jan 15;24(2):454-7. doi: 10.1016/j.bmcl.2013.12.049. Epub 2013 Dec 18.

Growth inhibitory activity for cancer cell lines of lapachol and its natural and semi-synthetic derivatives.

Author information

1
Dipartimento di Farmacia, Università 'G. D'Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo (CH), Italy.
2
Dipartimento di Farmacia, Università 'G. D'Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo (CH), Italy. Electronic address: fepifano@unich.it.
3
Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles, 1050 Brussels, Belgium.

Abstract

A series of 17 selected natural and semisynthetic 1,4-naphthoquinones were synthesized, and their growth inhibitory activity was evaluated in vitro. The compounds were tested on six human cancer cell lines using the MTT colorimetric assay. The data revealed that of the chemicals under study only lapachol, its acetate and 3-geranyllawsone displayed the highest activity, recording mean IC50 values ranging from 15 to 22 μM.

KEYWORDS:

1,4-Naphthoquinones; Cancer; In vitro growth inhibition; Lapachol

PMID:
24374273
DOI:
10.1016/j.bmcl.2013.12.049
[Indexed for MEDLINE]

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