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Arch Pediatr. 2013 Nov;20 Suppl 3:S94-8. doi: 10.1016/S0929-693X(13)71416-7.

[Prophylactic antibiotics for immunocompromised children].

[Article in French]

Author information

Service d'hémato-oncologie pédiatrique, CHU de Nice, hôpital Archet 2, 151 route de Sainte-Antoine, 06200 Nice, France. Electronic address:
Centre d'étude des déficits immunitaires, CHU Necker-Enfants malades, 149 rue de Sèvres, 75015 Paris, France.
Urgences pédiatriques-infectiologie, hôpitaux pédiatriques CHU Lenval, 57 avenue de la Californie, 06200 Nice, France; Groupe de pathologie infectieuse pédiatrique (GPIP) de la Société française de pédiatrie.


Infections are the most common cause of morbidity and mortality in pediatric immunocompromised children. The emergence of pan-drug resistant bacteria is particularly concerning for these patients. The risk of infection can be reduced by educational rules, immunizing these patients and sometimes antibiotic prophylaxis. But the individual level of risk is very difficult to assess. Using antibiotics may lead to adverse effects such as allergic reactions, cross-reactions with other drugs, development of super-infections, pseudomembranous colitis and overall development of antibioticresistant bacterial strains. Recommendations for preventing infections in these patients exist for specific case such as inherited disorder or stem cell transplantation. In others cases it depends on physicians' habits: the increase of bacterial resistance could lead to reduce the prescriptions non evidence based and not included in official guidelines. Pneumococcal and meningococcal vaccinations might change guidelines and habits.

[Indexed for MEDLINE]

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