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J Neuroimmunol. 2014 Jan 15;266(1-2):12-23. doi: 10.1016/j.jneuroim.2013.10.014. Epub 2013 Nov 9.

IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination.

Author information

  • 1Department of Neurology, The University of Chicago, Chicago, IL 60637, USA; Committee on Neurobiology, The University of Chicago, Chicago, IL 60637, USA.
  • 2Department of Neurology, The University of Chicago, Chicago, IL 60637, USA.
  • 3Department of Neurology, The University of Chicago, Chicago, IL 60637, USA; Committee on Neurobiology, The University of Chicago, Chicago, IL 60637, USA. Electronic address: rkraig@neurology.bsd.uchicago.edu.

Abstract

Dendritic cells (DCs) release exosomes with different characteristics based on stimulus. Here, we showed that DC cultures stimulated with low-level IFNγ released exosomes (IFNγ-DC-Exos) that contained microRNA species that can increase baseline myelination, reduce oxidative stress, and improve remyelination following acute lysolecithin-induced demyelination. Furthermore, nasally administered IFNγ-DC-Exos increased CNS myelination in vivo. IFNγ-DC-Exos were preferentially taken up by oligodendrocytes, suggesting that they directly impact oligodendrocytes to increase myelination. Thus, our results show great potential for use of these IFNγ-DC-Exos as a therapeutic to promote remyelination in multiple sclerosis and dysmyelinating syndromes.

KEYWORDS:

Demyelination; Dendritic cell; Exosomes; MicroRNA; Multiple sclerosis; Myelin

PMID:
24275061
PMCID:
PMC3920591
DOI:
10.1016/j.jneuroim.2013.10.014
[PubMed - indexed for MEDLINE]
Free PMC Article
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