Format

Send to

Choose Destination
Anal Chem. 2013 Dec 17;85(24):11732-8. doi: 10.1021/ac402689t. Epub 2013 Dec 3.

Development of a Standard Reference Material for metabolomics research.

Author information

1
Biomolecular Measurement Division, #Chemical Sciences Division, and â–¡Biosystems and Biomaterials Division, National Institute of Standards and Technology , Gaithersburg, Maryland 20899, United States.

Abstract

The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NIH), has developed a Standard Reference Material (SRM) to support technology development in metabolomics research. SRM 1950 Metabolites in Human Plasma is intended to have metabolite concentrations that are representative of those found in adult human plasma. The plasma used in the preparation of SRM 1950 was collected from both male and female donors, and donor ethnicity targets were selected based upon the ethnic makeup of the U.S. population. Metabolomics research is diverse in terms of both instrumentation and scientific goals. This SRM was designed to apply broadly to the field, not toward specific applications. Therefore, concentrations of approximately 100 analytes, including amino acids, fatty acids, trace elements, vitamins, hormones, selenoproteins, clinical markers, and perfluorinated compounds (PFCs), were determined. Value assignment measurements were performed by NIST and the Centers for Disease Control and Prevention (CDC). SRM 1950 is the first reference material developed specifically for metabolomics research.

PMID:
24187941
PMCID:
PMC4823010
DOI:
10.1021/ac402689t
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Chemical Society Icon for PubMed Central
Loading ...
Support Center