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Bone. 2014 Jan;58:55-8. doi: 10.1016/j.bone.2013.10.007. Epub 2013 Oct 17.

Positive effects of brown adipose tissue on femoral bone structure.

Author information

1
Department of Radiology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA. Electronic address: mbredella@partners.org.

Abstract

PURPOSE:

Recent studies suggest a link between brown adipose tissue (BAT) and bone. The purpose of our study was to investigate the effects of BAT on femoral bone structure.

MATERIALS AND METHODS:

We studied 105 patients (19 m, 86 f. mean age 45.5±16.1 years) who underwent F18-FDG positron emission tomography/computed tomography (PET/CT) for benign etiologies (n=20) or follow-up of successfully treated malignancies (n=85); mean time between PET/CT and last form of treatment was 14.8±18.0 months. BAT volume by PET/CT; femoral bone structure by CT (total femoral cross-sectional area (CSA), cortical CSA); and thigh muscle CSA and thigh subcutaneous fat CSA by CT was assessed.

RESULTS:

There were positive correlations between BAT volume and total femoral CSA and cortical CSA, independent of age, BMI and history of malignancy (p<0.05). BAT volume correlated positively with thigh muscle CSA and thigh fat CSA (p<0.05). When total femoral CSA was entered as a dependent variable and BAT volume, age and BMI as independent variables in a forward stepwise regression model, BAT volume was the only predictor of total femoral CSA. When femoral cortical CSA was entered as a dependent variable and BAT volume, age and BMI as independent variables, BAT volume was the only predictor of femoral cortical CSA.

CONCLUSION:

BAT volume is a positive predictor of femoral bone structure and correlates positively with thigh muscle and subcutaneous fat, possibly mediated by muscle. These results provide further evidence of a positive effect of BAT on bone.

KEYWORDS:

Bone; Brown adipose tissue (BAT); Fat; Muscle; Structure

PMID:
24140784
PMCID:
PMC3855336
DOI:
10.1016/j.bone.2013.10.007
[Indexed for MEDLINE]
Free PMC Article

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