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Clin Proteomics. 2013 Oct 14;10(1):14. doi: 10.1186/1559-0275-10-14.

Proteomic profiling of serum samples from chikungunya-infected patients provides insights into host response.

Author information

1
Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India.
2
Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110 029, India.
3
Microtest Innovations Pvt. Limited, International Technology Park, Bangalore 560 066, India.
4
McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore 21205 MD, USA.
5
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore 21205 MD, USA.
6
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore 21205 MD, USA.
7
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore 21205 MD, USA.
#
Contributed equally

Abstract

BACKGROUND:

Chikungunya is a highly debilitating febrile illness caused by Chikungunya virus, a single-stranded RNA virus, which is transmitted by Aedes aegypti or Aedes albopictus mosquito species. The pathogenesis and host responses in individuals infected with the chikungunya virus are not well understood at the molecular level. We carried out proteomic profiling of serum samples from chikungunya patients in order to identify molecules associated with the host response to infection by this virus.

RESULTS:

Proteomic profiling of serum obtained from the infected individuals resulted in identification of 569 proteins. Of these, 63 proteins were found to be differentially expressed (≥ 2-fold) in patient as compared to control sera. These differentially expressed proteins were involved in various processes such as lipid metabolism, immune response, transport, signal transduction and apoptosis.

CONCLUSIONS:

This is the first report providing a global proteomic profile of serum samples from individuals infected with the chikungunya virus. Our data provide an insight into the proteins that are involved as host response factors during an infection. These proteins include clusterin, apolipoproteins and S100A family of proteins.

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