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J Virol. 2013 Dec;87(24):13922-6. doi: 10.1128/JVI.02500-13. Epub 2013 Oct 9.

Contributions of herpes simplex virus 1 envelope proteins to entry by endocytosis.

Author information

1
Department of Veterinary Microbiology and Pathology, Washington State University.

Abstract

Herpes simplex virus (HSV) proteins specifically required for endocytic entry but not direct penetration have not been identified. HSVs deleted of gE, gG, gI, gJ, gM, UL45, or Us9 entered cells via either pH-dependent or pH-independent endocytosis and were inactivated by mildly acidic pH. Thus, the required HSV glycoproteins, gB, gD, and gH-gL, may be sufficient for entry regardless of entry route taken. This may be distinct from entry mechanisms employed by other human herpesviruses.

PMID:
24109213
PMCID:
PMC3838226
DOI:
10.1128/JVI.02500-13
[Indexed for MEDLINE]
Free PMC Article

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