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J Crit Care. 2014 Feb;29(1):101-6. doi: 10.1016/j.jcrc.2013.08.016. Epub 2013 Sep 24.

A pilot investigation of the association of genetic polymorphisms regulating corticotrophin-releasing hormone with posttraumatic stress and depressive symptoms in medical-surgical intensive care unit survivors.

Author information

1
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. Electronic address: ddavydo1@u.washington.edu.
2
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.
3
Department of Medicine, University of Washington, Seattle, WA, USA.

Abstract

PURPOSE:

To determine if single nucleotide polymorphisms of the corticotrophin-releasing hormone binding protein (CRHBP, rs10055255) and CRH receptor type 1 (CRHR1, rs1876831) were associated with posttraumatic stress disorder (PTSD) and depressive symptoms following medical-surgical intensive care unit (ICU) hospitalization.

MATERIALS AND METHODS:

We extracted DNA for genotyping from saliva samples of 93 ICU patients enrolled in a prospective cohort investigation. Follow-up interviews conducted 3 and 12-months post-ICU included assessment of PTSD symptoms with the PTSD Checklist-Civilian Version and depressive symptoms with the Patient Health Questionnaire-9.

RESULTS:

Homozygosity for the CRHBP rs10055255 T allele was associated with significantly fewer post-ICU PTSD (β = -10.8, 95% confidence interval [95% CI], -17.7 to -3.9; P = .002) and depressive symptoms (β = -3.7, 95% CI, -6.7 to -0.7; P = .02). Carrying a CRHR1 rs1876831 C allele was associated with significantly more post-ICU depressive symptoms compared to T/T homozygotes (C/T heterozygtes: β = 6.9, 95% CI, 1.2-12.6; P = .02; C/C homozygotes: β = 5.8; 95% CI: 0.2-11.3; P = .04). These associations remained significant after adjustment for age, race, illness severity, and in-ICU steroid exposure.

CONCLUSIONS:

Despite a small sample size, our findings suggest a potential role for genetic variants of CRHBP and CRHR1 in the development of post-ICU psychiatric morbidity.

KEYWORDS:

Corticotrophin-releasing hormone binding protein; Corticotrophin-releasing hormone receptor-type 1; Critical care; Depression; Posttraumatic stress disorder

PMID:
24075295
PMCID:
PMC3865113
DOI:
10.1016/j.jcrc.2013.08.016
[Indexed for MEDLINE]
Free PMC Article

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