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Cancer Gene Ther. 2013 Nov;20(11):638-41. doi: 10.1038/cgt.2013.57. Epub 2013 Sep 13.

Oral contrast enhances the resolution of in-life NIS reporter gene imaging.

Author information

1
Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.

Abstract

Sodium iodide symporter (NIS) reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as the spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium sulfate enhances CT definition of the stomach, masks background gamma ray emissions from the stomach and enhances signal detection from radiotracer uptake in NIS-transduced organs.

PMID:
24030210
PMCID:
PMC3867790
DOI:
10.1038/cgt.2013.57
[Indexed for MEDLINE]
Free PMC Article

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