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J Hypertens. 2013 Nov;31(11):2136-41; discussion 2141. doi: 10.1097/HJH.0b013e3283642f18.

Association of hypermagnesemia and blood pressure in the critically ill.

Author information

1
aBeth Israel Deaconess Medical Center, Department of Medicine bHarvard-MIT Division of Health Sciences and Technology cSchool of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada.

Abstract

BACKGROUND:

Although magnesium is important in the biology of blood pressure regulation, little clinical data exist on the association of hypermagnesemia and blood pressure.

METHOD:

We examined the association of hypermagnesemia and SBP in a cross-sectional study of 10 521 ICU patients from a single tertiary care medical center, 6% of whom had a serum magnesium above 2.6 mg/dl at time of admission.

RESULTS:

In a multivariable analysis, hypermagnesemia was associated with SBP 6.2 mmHg lower [95% confidence interval (CI) -8.2, -4.2, P < 0.001] than in patients with admission values of serum magnesium 2.6 mg/dl or less. Each mg/dl increase in serum magnesium was associated with a decrease in SBP of 4.3 mmHg (95% CI -5.5, -3.1, P < 0.001). In addition, hypermagnesemic patients had a 2.48-fold greater likelihood (95% CI 2.06, 3.00, P < 0.001) of receiving intravenous vasopressors during the first 24 h of ICU care, independent of admission SBP.

CONCLUSION:

Our findings add support to the biologic importance of magnesium regulation in blood pressure control.

PMID:
24029865
PMCID:
PMC5682028
DOI:
10.1097/HJH.0b013e3283642f18
[Indexed for MEDLINE]
Free PMC Article

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