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Oxid Med Cell Longev. 2013;2013:187301. doi: 10.1155/2013/187301. Epub 2013 Jul 25.

Effects of resveratrol on daily rhythms of locomotor activity and body temperature in young and aged grey mouse lemurs.

Author information

1
Mécanismes Adaptatifs et Evolution, UMR 7179 Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, Brunoy, France. pifferi@mnhn.fr

Abstract

In several species, resveratrol, a polyphenolic compound, activates sirtuin proteins implicated in the regulation of energy balance and biological clock processes. To demonstrate the effect of resveratrol on clock function in an aged primate, young and aged mouse lemurs (Microcebus murinus) were studied over a 4-week dietary supplementation with resveratrol. Spontaneous locomotor activity and daily variations in body temperature were continuously recorded. Reduction in locomotor activity onset and changes in body temperature rhythm in resveratrol-supplemented aged animals suggest an improved synchronisation on the light-dark cycle. Resveratrol could be a good candidate to restore the circadian rhythms in the elderly.

PMID:
23983895
PMCID:
PMC3745962
DOI:
10.1155/2013/187301
[Indexed for MEDLINE]
Free PMC Article

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