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J Infect Dis. 2014 Feb 1;209(3):468-72. doi: 10.1093/infdis/jit446. Epub 2013 Aug 20.

Schistosomiasis japonica during pregnancy is associated with elevated endotoxin levels in maternal and placental compartments.

Author information

1
Center for International Health Research.

Abstract

Schistosomiasis affects approximately 40 million women of reproductive age and has been linked to elevated levels of circulating endotoxin in nonpregnant individuals. We have evaluated endotoxin levels in maternal, placental, and newborn blood collected from women residing in Leyte, Philippines. Endotoxin levels in both maternal and placental compartments in pregnant women with schistosomiasis were 1.3- and 2.4-fold higher, respectively, than in uninfected women. In addition, higher concentrations of endotoxin in placental blood were associated with premature birth, acute chorioamnionitis, and elevated proinflammatory cytokines. By promoting endotoxemia, schistosomiasis may exert additional, maladaptive influences on pregnancy outcomes.

KEYWORDS:

S. japonicum; endotoxin; pregnancy

PMID:
23964108
PMCID:
PMC3883168
DOI:
10.1093/infdis/jit446
[Indexed for MEDLINE]
Free PMC Article

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