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PLoS One. 2013 Jul 23;8(7):e69286. doi: 10.1371/journal.pone.0069286. Print 2013.

P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury.

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Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California, United States of America.


Fas-associated death domain (DD) adaptor (FADD), a member of the DD superfamily, contains both a DD and a death effector domain (DED) that are important in mediating FAS ligand-induced apoptotic signaling. P45 is a unique member of the DD superfamily in that it has a domain with sequence and structural characteristics of both DD and DED. We show that p45 forms a complex with FADD and diminishes Fas-FADD mediated death signaling. The DED of FADD is required for the complex formation with p45. Following spinal cord injury, transgenic mice over-expressing p45 exhibit increased neuronal survival, decreased retraction of corticospinal tract fibers and improved functional recovery. Understanding p45-mediated cellular and molecular mechanisms may provide insights into facilitating nerve regeneration in humans.

[Indexed for MEDLINE]
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