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Exp Biol Med (Maywood). 2013 May;238(5):539-48. doi: 10.1177/1535370213489437.

Follicle growth, ovulation, and luteal formation in primates and rodents: a comparative perspective.

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Department of OB/GYN & Reproductive Sciences, University of Maryland Baltimore, Baltimore, MD, USA.


Ovarian function has a great deal of functional overlap between species; antral follicles grow in response to FSH, ovulation involves proteolysis, and the steroidogenic pathway is largely the same. However, embedded in these similarities are important differences that reflect the evolutionary and natural history of species and may focus future research into these critical areas. This review compares ovarian function of rats and mice with primates, focusing on estradiol and follicle growth, steroidogenesis and rupture during the periovulatory interval, and the formation of a functional corpus luteum, drawing the conclusion that careful comparison of species yields more functional information about both than studying them in isolation.


Ovary; corpus luteum; granulosa; ovulation; primate; rodent

[Indexed for MEDLINE]

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