Format

Send to

Choose Destination
Gut Microbes. 2013 Nov-Dec;4(6):532-40. doi: 10.4161/gmic.25720. Epub 2013 Jul 12.

Biomarkers of Helicobacter pylori-associated gastric cancer.

Author information

1
Departments of Medicine and Microbiology & Immunology; University of California; Davis School of Medicine; Davis, CA USA; Center for Comparative Medicine; University of California; Davis School of Medicine; Davis, CA USA.
2
Infectious Diseases Research Unit; Instituto Mexicano del Seguro Social; Mexico City, Mexico.
3
Departments of Medicine and Microbiology & Immunology; University of California; Davis School of Medicine; Davis, CA USA; Center for Comparative Medicine; University of California; Davis School of Medicine; Davis, CA USA; California National Primate Research Center; University of California; Davis School of Medicine; Davis, CA USA.

Abstract

Helicobacter pylori-associated gastric cancer is a major cause of morbidity and mortality worldwide, and is predicted to become even more common in developing countries as the population ages. Since gastric cancer develops slowly over years to decades, and typically progresses though a series of well-defined histologic stages, cancer biomarkers have potential to identify asymptomatic individuals in whom surgery might be curative, or even those for whom antibiotics to eradicate H. pylori could prevent neoplastic transformation. Here we describe some of the challenges of biomarker discovery, summarize current approaches to biomarkers of gastric cancer, and explore some recent novel strategies.

KEYWORDS:

biomarkers; gastric cancer; helicobacter pylori

PMID:
23851317
PMCID:
PMC3928163
DOI:
10.4161/gmic.25720
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center