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Opt Lett. 2013 Jul 1;38(13):2339-41. doi: 10.1364/OL.38.002339.

X-ray luminescence optical tomography imaging: experimental studies.

Author information

1
School of Engineering, University of California, Merced, California 95343, USA. cli32@ucmerced.edu

Abstract

We present a hybrid imaging modality, x-ray luminescence optical tomography (XLOT), in which collimated x-ray beams are used to excite phosphor-based contrast agents. Images are reconstructed from the optical signals, using the known x-ray beam location and spatial extent as priors. We demonstrate XLOT using phantom experiments with deep targets and show that the reconstructed signal varies by <12% when the depth changes from 4.2 to 7.7 mm. For simple source distributions, we find as few as two orthogonal projection measurements are sufficient for XLOT reconstruction.

PMID:
23811921
PMCID:
PMC5204368
DOI:
10.1364/OL.38.002339
[Indexed for MEDLINE]
Free PMC Article

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