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Cancer Biol Ther. 2013 Jun;14(6):521-6. doi: 10.4161/cbt.24347.

Dietary supplemented 2-mercaptoethanol prevents spontaneous and delays virally-induced murine mammary tumorigenesis.

Author information

1
University of Minnesota; Minneapolis, MN, USA. mbclicker@msn.com

Abstract

There seems to be little doubt that organosulfur compounds have enormous benefits for biological processes, especially those of diseases like cancer. The preliminary results herein define a cancer model in which benefits/mechanisms of multitudes of xenobiotic and nature's organosulfurs could easily be compared. Mice from three strains with a high incidence for naturally occurring tumors were treated daily with 2-mercaptoethanol (2-Me) starting at weaning. The 100% tumor incidence of undefined etiology in untreated BXSB-Yaa (+) males was completely prevented by 2-Me. In contrast, 2-Me treatment of female and male C3H.OL and C3H.OH congenic strains, did not change the 100% tumor incidence due to milk-borne retrovirus, MMTV(S), but did: (1) delay the appearance of tumors by 42%; (2) increase longevity 56%; and (3) increase longevity, post-tumor detection, 95%. The addition of these results to the increasingly impressive anti-cancer benefits of simple xenobiotic organosulfurs raise the question: Can they be adapted for use as a preventive modality for human cancer?

KEYWORDS:

2-mercaptoethanol; MMTV; cancer prophylaxis; dietary; experimental; garlic; murine mammary tumors; organosulfurs; retrovirus

PMID:
23760494
PMCID:
PMC3813568
DOI:
10.4161/cbt.24347
[Indexed for MEDLINE]
Free PMC Article

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