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Aging Cell. 2013 Jun;12(3):518-22. doi: 10.1111/acel.12067.

FOXO4 is necessary for neural differentiation of human embryonic stem cells.

Author information

1
Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Proteostasis is critical for maintaining cell function and proteome stability may play an important role in human embryonic stem cell (hESC) immortality. Notably, hESC populations exhibit a high assembly of active proteasomes, a key node of the proteostasis network. FOXO4, an insulin/IGF-1 responsive transcription factor, regulates proteasome activity in hESCs. We find that loss of FOXO4 reduces the potential of hESCs to differentiate into neural lineages. Therefore, FOXO4 crosses evolutionary boundaries and links hESC function to invertebrate longevity modulation.

PMID:
23551888
PMCID:
PMC4864013
DOI:
10.1111/acel.12067
[Indexed for MEDLINE]
Free PMC Article

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