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J Neurosci. 2013 Mar 27;33(13):5584-9. doi: 10.1523/JNEUROSCI.2944-12.2013.

Axonal translation of β-catenin regulates synaptic vesicle dynamics.

Author information

1
University of North Carolina at Chapel Hill, Joint Department of Biomedical Engineering, Chapel Hill, North Carolina 27599, USA. amtaylor@unc.edu

Abstract

Many presynaptic transcripts have been observed in axons, yet their role in synapse development remains unknown. Using visually and pharmacologically isolated presynaptic terminals from dissociated rat hippocampal neurons, we found that ribosomes and β-catenin mRNA preferentially localize to recently formed boutons. Locally translated β-catenin accumulates at presynaptic terminals, where it regulates synaptic vesicle release dynamics. Thus, local translation of β-catenin is a newly described mechanism for axons to independently functionalize nerve terminals at great distances from cellular somata.

PMID:
23536073
PMCID:
PMC3651888
DOI:
10.1523/JNEUROSCI.2944-12.2013
[Indexed for MEDLINE]
Free PMC Article

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