Parallel PARKing: Parkinson's genes function in common pathway

Rosalind S Chuang; Aaron D Gitler

doi:10.1016/j.neuron.2013.01.014

Parallel PARKing: Parkinson's genes function in common pathway

Neuron. 2013 Feb 6;77(3):377-9. doi: 10.1016/j.neuron.2013.01.014.

Authors

Rosalind S Chuang¹, Aaron D Gitler

Affiliation

¹ Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA. rschuang@stanford.edu

PMID: 23395366
DOI: 10.1016/j.neuron.2013.01.014

Abstract

Parkinson's disease (PD) is associated with diverse genetic and environmental susceptibilities. Functional connections between PD genes have remained elusive. In this issue of Neuron, MacLeod et al. (2013) link three PD susceptibility genes, LRRK2, PARK16, and VSP35, to a common cellular pathway and show how these deficits contribute to dysfunction.

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