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J Altern Complement Med. 2013 Oct;19(10):838-42. doi: 10.1089/acm.2012.0296. Epub 2013 Feb 5.

Comparison of Xilei-san, a Chinese herbal medicine, and dexamethasone in mild/moderate ulcerative proctitis: a double-blind randomized clinical trial.

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1
1 Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou, People's Republic of China .

Abstract

BACKGROUND:

Xilei-san is a traditional Chinese herbal medicine that has proven to be of possible use in the treatment of ulcerative proctitis (UP) in a pilot study.

OBJECTIVES:

This study was intended to compare Xilei-san with dexamethasone enemas in subjects with mild-to-moderate active UP.

METHODS:

A double-blind randomized study was performed in 35 subjects. During the initial 8 weeks, the subjects received an enema of Xilei-san or dexamethasone at bedtime, then discontinued the treatment and were followed for 12 weeks. All of the subjects received 3 g/day oral mesalazine during the entire study. The disease activity was assessed at inclusion and at weeks 4, 8, and 20.

RESULTS:

Both treatments showed significant improvement in clinical, endoscopic, and histological grades in comparison with the baseline.

CONCLUSIONS:

Xilei-san enemas are comparable to dexamethasone enemas in this study. This medicine is safe, well accepted, and may be an alternative drug in the treatment of mild-to-moderate active UP.

PMID:
23383973
DOI:
10.1089/acm.2012.0296
[Indexed for MEDLINE]

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