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Nat Chem Biol. 2013 Apr;9(4):244-6. doi: 10.1038/nchembio.1178. Epub 2013 Feb 3.

Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1.

Author information

1
Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California, USA.

Abstract

We identify an Arabidopsis pyridoxal-phosphate-dependent aminotransferase, VAS1, whose loss-of-function simultaneously increases amounts of the phytohormone auxin and the ethylene precursor 1-aminocyclopropane-1-carboxylate. VAS1 uses the ethylene biosynthetic intermediate methionine as an amino donor and the auxin biosynthetic intermediate indole-3-pyruvic acid as an amino acceptor to produce L-tryptophan and 2-oxo-4-methylthiobutyric acid. Our data indicate that VAS1 serves key roles in coordinating the amounts of these two vital hormones.

PMID:
23377040
PMCID:
PMC3948326
DOI:
10.1038/nchembio.1178
[Indexed for MEDLINE]
Free PMC Article

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