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Am J Physiol Regul Integr Comp Physiol. 2013 Mar 15;304(6):R393-406. doi: 10.1152/ajpregu.00584.2012. Epub 2013 Jan 30.

Mitochondrial morphology transitions and functions: implications for retrograde signaling?

Author information

1
Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.

Abstract

In response to cellular and environmental stresses, mitochondria undergo morphology transitions regulated by dynamic processes of membrane fusion and fission. These events of mitochondrial dynamics are central regulators of cellular activity, but the mechanisms linking mitochondrial shape to cell function remain unclear. One possibility evaluated in this review is that mitochondrial morphological transitions (from elongated to fragmented, and vice-versa) directly modify canonical aspects of the organelle's function, including susceptibility to mitochondrial permeability transition, respiratory properties of the electron transport chain, and reactive oxygen species production. Because outputs derived from mitochondrial metabolism are linked to defined cellular signaling pathways, fusion/fission morphology transitions could regulate mitochondrial function and retrograde signaling. This is hypothesized to provide a dynamic interface between the cell, its genome, and the fluctuating metabolic environment.

PMID:
23364527
PMCID:
PMC3602821
DOI:
10.1152/ajpregu.00584.2012
[Indexed for MEDLINE]
Free PMC Article

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