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Mov Disord. 2013 Mar;28(3):380-3. doi: 10.1002/mds.25319. Epub 2013 Jan 21.

Caffeine consumption and risk of dyskinesia in CALM-PD.

Author information

1
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Abstract

BACKGROUND:

Adenosine A2A receptor antagonists reduce or prevent the development of dyskinesia in animal models of levodopa-induced dyskinesia.

METHODS:

We examined the association between self-reported intake of the A2A receptor antagonist caffeine and time to dyskinesia in the Comparison of the Agonist Pramipexole with Levodopa on Motor Complications of Parkinson's Disease (CALM-PD) and CALM Cohort extension studies, using a Cox proportional hazards model adjusting for age, baseline Parkinson's severity, site, and initial treatment with pramipexole or levodopa.

RESULTS:

For subjects who consumed >12 ounces of coffee/day, the adjusted hazard ratio for the development of dyskinesia was 0.61 (95% CI, 0.37-1.01) compared with subjects who consumed <4 ounces/day. For subjects who consumed between 4 and 12 ounces/day, the adjusted hazard ratio was 0.73 (95% CI, 0.46-1.15; test for trend, P = .05).

CONCLUSIONS:

These results support the possibility that caffeine may reduce the likelihood of developing dyskinesia.

PMID:
23339054
PMCID:
PMC3608707
DOI:
10.1002/mds.25319
[Indexed for MEDLINE]
Free PMC Article

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