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J Hepatol. 2013 May;58(5):984-92. doi: 10.1016/j.jhep.2013.01.006. Epub 2013 Jan 16.

Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

Author information

1
INRA, TOXALIM (Research Centre in Food Toxicology), Toulouse, France.

Abstract

BACKGROUND & AIMS:

Nutrients influence non-alcoholic fatty liver disease. Essential fatty acids deficiency promotes various syndromes, including hepatic steatosis, through increased de novo lipogenesis. The mechanisms underlying such increased lipogenic response remain unidentified.

METHODS:

We used wild type mice and mice lacking Liver X Receptors to perform a nutrigenomic study that aimed at examining the role of these transcription factors.

RESULTS:

We showed that, in the absence of Liver X Receptors, essential fatty acids deficiency does not promote steatosis. Consistent with this, Liver X Receptors are required for the elevated expression of genes involved in lipogenesis in response to essential fatty acids deficiency.

CONCLUSIONS:

This work identifies, for the first time, the central role of Liver X Receptors in steatosis induced by essential fatty acids deficiency.

PMID:
23333450
DOI:
10.1016/j.jhep.2013.01.006
[Indexed for MEDLINE]

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