Format

Send to

Choose Destination
Curr Opin Cell Biol. 2013 Apr;25(2):195-9. doi: 10.1016/j.ceb.2012.12.001. Epub 2012 Dec 29.

Cytotopic localization by long noncoding RNAs.

Author information

1
Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford, CA 94305, USA.

Abstract

Cells are highly organized structures. In addition to membrane delimited organelles, proteins and RNAs can organize themselves into specific domains. Some examples include stress granules and subnuclear bodies. This level of organization is essential for the correct execution of multiple processes in the cell, ranging from cell signaling to assembly of structures such as the ribosomes. Here we will review evidence that noncoding RNAs play a critical role in the establishment and regulation of these domains. The unique abilities of RNA to mark the genome in a gene-specific and condition-specific manner and to serve as tethers nominate them as ideal molecular address codes.

PMID:
23279909
PMCID:
PMC3633454
DOI:
10.1016/j.ceb.2012.12.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center