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Nat Rev Mol Cell Biol. 2013 Jan;14(1):55-61. doi: 10.1038/nrm3496.

Protein homeostasis: live long, won't prosper.

Author information

1
Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

Abstract

Protein turnover is an effective way of maintaining a functional proteome, as old and potentially damaged polypeptides are destroyed and replaced by newly synthesized copies. An increasing number of intracellular proteins, however, have been identified that evade this turnover process and instead are maintained over a cell's lifetime. This diverse group of long-lived proteins might be particularly prone to accumulation of damage and thus have a crucial role in the functional deterioration of key regulatory processes during ageing.

PMID:
23258296
PMCID:
PMC3570024
DOI:
10.1038/nrm3496
[Indexed for MEDLINE]
Free PMC Article

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