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Biochemistry (Mosc). 2012 Dec;77(12):1382-6. doi: 10.1134/S0006297912120061.

Effect of plastoquinone derivative 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) on estrous cycle and 17β-estradiol level in rats.

Author information

1
Research Institute of Biology of Southern Federal University, pr. Stachki 194/1, 344090 Rostov-on-Don, Russia. vladimirchi@yandex.ru

Abstract

Administration of the plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) to female Wistar rats with regular estrous cycle once a day for two weeks at doses of 25 nmol/kg (but not 250 nmol/kg) leads to increase in proestrus duration by reducing the phase of diestrus and metestrus. Neither dose caused significant changes in serum 17β-estradiol level for any stage of the cycle. However, relative elongation of the proestrus stage leads to an increase in average per cycle estradiol levels by 20%.

PMID:
23244734
DOI:
10.1134/S0006297912120061
[Indexed for MEDLINE]

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