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Ther Drug Monit. 2012 Dec;34(6):739-41. doi: 10.1097/FTD.0b013e318271b6e6.

Pharmacogenetic determinant of the drug interaction between tacrolimus and omeprazole.

Author information

1
AP-HP, Department of Pediatric Pharmacology and Pharmacogenetics, Hôpital Robert Debré, INSERM, Paris, France.

Abstract

A 17-year-old adolescent with acute nephrotoxicity had CYP3A4-5, CYP2C19, and ABCB1 genotyping performed to understand a suspected drug interaction between tacrolimus and omeprazole. The determinant role of individual pharmacogenetic profile in the occurrence of tacrolimus nephrotoxicity is presented and discussed.

PMID:
23042259
DOI:
10.1097/FTD.0b013e318271b6e6
[Indexed for MEDLINE]

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