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J Med Chem. 2012 Nov 26;55(22):10282-6. doi: 10.1021/jm300871x. Epub 2012 Nov 12.

Structures of human acetylcholinesterase in complex with pharmacologically important ligands.

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1
New York Structural Biology Center, New York, New York 10027, USA.

Abstract

Human acetylcholinesterase (AChE) is a significant target for therapeutic drugs. Here we present high resolution crystal structures of human AChE, alone and in complexes with drug ligands; donepezil, an Alzheimer's disease drug, binds differently to human AChE than it does to Torpedo AChE. These crystals of human AChE provide a more accurate platform for further drug development than previously available.

PMID:
23035744
DOI:
10.1021/jm300871x
[Indexed for MEDLINE]

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