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Trends Biochem Sci. 2012 Nov;37(11):466-76. doi: 10.1016/j.tibs.2012.08.001. Epub 2012 Sep 6.

The great unravelling: chromatin as a modulator of the aging process.

Author information

1
The Salk Institute for Biological Studies, Molecular and Cellular Biology Department, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

During embryogenesis, the establishment of chromatin states permits the implementation of genetic programs that allow the faithful development of the organism. However, these states are not fixed and there is much evidence that stochastic or chronic deterioration of chromatin organization, as correlated by transcriptional alterations and the accumulation of DNA damage in cells, occurs during the lifespan of the individual. Whether causal or simply a byproduct of macromolecular decay, these changes in chromatin states have emerged as potentially central conduits of mammalian aging. This review explores the current state of our understanding of the links between chromatin organization and aging.

PMID:
22959736
PMCID:
PMC3482262
DOI:
10.1016/j.tibs.2012.08.001
[Indexed for MEDLINE]
Free PMC Article

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