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J Org Chem. 2013 Jan 4;78(1):35-41. doi: 10.1021/jo3014484. Epub 2012 Sep 14.

Total synthesis of (-)-sessilifoliamide J.

Author information

1
Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, P. R. China.

Abstract

An efficient synthesis of the Stemona alkaloid (-)-sessilifoliamide J (1) in 12 steps and 7.7% overall yield from the known building block 8 is presented. The synthesis features the Corey lactonization reaction and a highly diastereoselective α-methylation reaction to build the spiro-lactone moiety.

PMID:
22946828
DOI:
10.1021/jo3014484
[Indexed for MEDLINE]

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