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Autophagy. 2012 Oct;8(10):1523-5. doi: 10.4161/auto.21154. Epub 2012 Aug 15.

Autophagy induction by vitamin D inhibits both Mycobacterium tuberculosis and human immunodeficiency virus type 1.

Author information

1
Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, CA, USA.

Abstract

Low vitamin D levels in human immunodeficiency virus type-1 (HIV) infected persons are associated with more rapid disease progression and increased risk for Mycobacterium tuberculosis infection. We report that physiological concentrations of 1α,25-dihydroxycholecalciferol (1,25D3), the active form of vitamin D, inhibits M. tuberculosis and HIV replication in co-infected macrophages through human cathelicidin microbial peptide-dependent autophagy that requires phagosomal maturation. These findings provide a biological explanation for the importance of vitamin D sufficiency in HIV and M. tuberculosis-infected persons, and provide new insights into novel approaches to prevent and treat HIV infection and related opportunistic infections.

PMID:
22892387
PMCID:
PMC3679232
DOI:
10.4161/auto.21154
[Indexed for MEDLINE]
Free PMC Article

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