1. J Gerontol A Biol Sci Med Sci. 2013 Mar;68(3):226-34. doi: 10.1093/gerona/gls156.
Epub 2012 Jul 25.

D-chiro-inositol and pinitol extend the life span of Drosophila melanogaster.

Hada B(1), Yoo MR, Seong KM, Jin YW, Myeong HK, Min KJ.

Author information: 
(1)Department of Biological Sciences, 100 Inha St. Inha University Incheon
402-751, Korea.

D-chiro-inositol, a member of the inositol family, and pinitol, a 3-methoxy
analogue of D-chiro-inositol, have been proposed to have antidiabetic,
antiinflammatory, anticancer and stamina enhancing effects. We found that
supplementing the diet of Drosophila with D-chiro-inositol and pinitol extended
adult longevity in both male and female flies. Life span extension was
accompanied by protection against oxidative and starvation stresses, improvement 
in health span, and no reduction in fecundity. Pinitol increased the fly life
span, both in dietary restriction and in ad libitum conditions, suggesting that
pinitol increased life span in a manner that was independent of the dietary
restriction pathway. Nuclear localization of dFOXO increased in D-chiro-inositol 
and pinitol-fed flies when compared with controls. Pinitol treatment
significantly activated JNK and S6K, but not AKT, indicating that the activation 
of dFOXO by pinitol is acquired by the activation of S6K and JNK signaling.
Hence, our study indicated that D-chiro-inositol and pinitol could be novel
food-derived antiaging compounds.

DOI: 10.1093/gerona/gls156 
PMID: 22843669  [Indexed for MEDLINE]