Format

Send to

Choose Destination
Phytochemistry. 2012 Oct;82:158-65. doi: 10.1016/j.phytochem.2012.06.024. Epub 2012 Jul 23.

Sesquiterpenes from the conifer root rot pathogen Heterobasidion occidentale.

Author information

1
Department of Chemistry, Uppsala BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Abstract

Investigation of the production of secondary metabolites of Heterobasidion occidentale led to the isolation and identification of six sesquiterpenes (illudolone A and B, illudolactone A and B, deoxyfomannosin A and B) along with the well-known sesquiterpene fomannosin and the previously described benzohydrofuran fomannoxin. The structures and relative configurations of the compounds were determined by 1D and 2D NMR spectroscopic analysis as well as by HRMS. Their absolute configuration and biosynthesis were suggested and discussed in relation to fomannosin. Four compounds showed growth inhibiting activity against several basidiomycetes, Phlebiopsis gigantea, Phanerochaete chrysosporium and H. occidentale, and toxicity towards the moss Physcomitrella patens. In addition, one compound displayed activity against the bacterium Variovorax paradoxus as well as against the ascomycete Fusarium oxysporum.

PMID:
22831894
DOI:
10.1016/j.phytochem.2012.06.024
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center