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J Neuroendocrinol. 2012 Jul;24(7):1085-6. doi: 10.1111/j.1365-2826.2012.02316.x.

Apelin and vasopressin: two work better than one.

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INSERM, Laboratory of Central Neuropeptides and Regulations of Water Balance and Cardiovascular Functions, CIRB College de France, Paris, France.


Water retention in the kidney is known to be an active phenomenon, controlled by a neuropeptide: vasopressin. Water excretion was assumed to be a passive phenomenon, as a result of vasopressin release blockade. This simplistic view is incorrect because water excretion is also controlled by a diuretic neuropeptide, apelin, produced not only by several peripheral tissues, but also by hypothalamic neurones, in particular the vasopressin ones projecting to the posterior pituitary.

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