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Cancer Cell. 2012 May 15;21(5):595-6. doi: 10.1016/j.ccr.2012.04.033.

What a difference a phosphate makes: life or death decided by a single amino acid in MDM2.

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1
Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92130, USA.

Abstract

In this issue of Cancer Cell, Gannon and colleagues create genetically engineered mice to test the role phosphorylation plays in the modification of one serine long thought to play a critical role in controlling the activity of MDM2, one of p53's main negative regulators.

PMID:
22624708
DOI:
10.1016/j.ccr.2012.04.033
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