Format

Send to

Choose Destination
See comment in PubMed Commons below
J Opioid Manag. 2012 Mar-Apr;8(2):99-104.

Continuous hydromorphone for pain and sedation in mechanically ventilated infants and children.

Author information

1
Department of Pharmacy, Center for Pediatric Medicine, Children's Hospital Colorado, Aurora, Colorado, USA.

Abstract

OBJECTIVE:

To describe dosing regimens and efficacy of continuous infusion hydromorphone in mechanically ventilated children.

DESIGN:

Retrospective review.

SETTING:

Tertiary care, pediatric hospital.

PATIENTS:

Ninety-two critically ill children (<18 years old).

MAIN OUTCOME MEASURE(S):

Hydromorphone dosing requirements, concomitant pain and sedation therapy, patient-specific pain scores (using Face Legs Activity Cry Consolability [FLACC] pain scale), and possible adverse drug events related to therapy.

RESULTS:

Starting dose was 0.024 +/- 0.04 mg/kg/h. Maximum dose was 0.05 + 0.1 mg/kg/h. Duration of therapy was 182 +/- 169 hours. Most patients received additional pain and sedation therapy. Most mean daily FLACC scores (66 percent) were below 1. Less than 10 percent of scores were above 3; only 1 score was above 6. Mean FLACC score, when averaged per patient course, was 1.004 +/- 0.71. Extracorporeal membrane oxygenation (ECMO) patients had a significantly higher initial and maximum dosing requirement than non-ECMO patients (p = 0.001).

CONCLUSIONS:

Continuous infusion hydromorphone appears to be an effective adjunctive analgesic in mechanically ventilated children.

PMID:
22616315
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center