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Antimicrob Agents Chemother. 2012 Jul;56(7):3986-8. doi: 10.1128/AAC.00743-12. Epub 2012 May 14.

In vitro activity of TP-271 against Mycobacterium abscessus, Mycobacterium fortuitum, and Nocardia species.

Author information

1
VAMC, Syracuse, New York, USA. michael.cynamon@med.va.gov

Abstract

The in vitro activities of TP-271, a novel fluorocycline antimicrobial, against 22 isolates of Mycobacterium abscessus, 22 isolates of Mycobacterium fortuitum, and 19 isolates of Nocardia spp. were studied by a microtiter broth dilution method. The MIC(90)s for M. abscessus, M. fortuitum, and Nocardia spp. were 0.5 μg/ml, 0.03 μg/ml, and 8 μg/ml, respectively. TP-271 was significantly more active than the respective control drug in virtually all tests.

PMID:
22585214
PMCID:
PMC3393423
DOI:
10.1128/AAC.00743-12
[Indexed for MEDLINE]
Free PMC Article

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