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Nat Genet. 2012 May 13;44(6):720-4. doi: 10.1038/ng.2281.

Parallel domestication of the Shattering1 genes in cereals.

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1
Department of Agronomy, Kansas State University, Manhattan, Kansas, USA.

Abstract

A key step during crop domestication is the loss of seed shattering. Here, we show that seed shattering in sorghum is controlled by a single gene, Shattering1 (Sh1), which encodes a YABBY transcription factor. Domesticated sorghums harbor three different mutations at the Sh1 locus. Variants at regulatory sites in the promoter and intronic regions lead to a low level of expression, a 2.2-kb deletion causes a truncated transcript that lacks exons 2 and 3, and a GT-to-GG splice-site variant in the intron 4 results in removal of the exon 4. The distributions of these non-shattering haplotypes among sorghum landraces suggest three independent origins. The function of the rice ortholog (OsSh1) was subsequently validated with a shattering-resistant mutant, and two maize orthologs (ZmSh1-1 and ZmSh1-5.1+ZmSh1-5.2) were verified with a large mapping population. Our results indicate that Sh1 genes for seed shattering were under parallel selection during sorghum, rice and maize domestication.

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PMID:
22581231
PMCID:
PMC3532051
DOI:
10.1038/ng.2281
[Indexed for MEDLINE]
Free PMC Article

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