1. J Med Chem. 2012 May 10;55(9):4169-77. doi: 10.1021/jm2014315. Epub 2012 Apr 26.

Novel 1,2,4-triazolo[1,5-a]pyridines and their fused ring systems attenuate
oxidative stress and prolong lifespan of Caenorhabiditis elegans.

Mekheimer RA(1), Sayed AA, Ahmed EA.

Author information: 
(1)Department of Chemistry, Faculty of Science for Girls, King Abdulaziz
University, Jeddah, P.O. Box 50918, Jeddah 21533, Saudi Arabia. rmekh@yahoo.com

In this paper we report the synthesis of some novel 1,2,4-triazolo[1,5-a]pyridine
and azolotriazolopyridine ring systems. The products were screened for various
types of activity like antibacterial, antifungal, and antioxidative activity.
Compound 13 was found to pose an antioxidative activity. In addition, this
compound was found to extend the life span of Caenorhabiditis elegans under
standard laboratory conditions and reduces both heat and chemical induced
oxidative stress in C. elegans in a dose-dependent manner. Furthermore, treatment
of worms with compound 13 was found to significantly attenuate the formation of
advanced glycation end products and malondialdehyde in a dose-dependent manner.

DOI: 10.1021/jm2014315 
PMID: 22509764  [Indexed for MEDLINE]