Format

Send to

Choose Destination
Neurorehabil Neural Repair. 2012 Jul-Aug;26(6):556-69. doi: 10.1177/1545968311421934. Epub 2012 Feb 13.

Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey.

Author information

1
California State Polytechnic University, Pomona, CA, USA.

Abstract

BACKGROUND:

Reliable outcome measures are essential for preclinical modeling of spinal cord injury (SCI) in primates.

MEASURES:

need to be sensitive to both increases and decreases in function in order to demonstrate potential positive or negative effects of therapeutics.

OBJECTIVES:

To develop behavioral tests and analyses to assess recovery of function after SCI in the nonhuman primate.

METHODS:

In all, 24 male rhesus macaques were subjected to complete C7 lateral hemisection. The authors scored recovery of function in an open field and during hand tasks in a restraining chair. In addition, EMG analyses were performed in the open field, during hand tasks, and while animals walked on a treadmill. Both control and treated monkeys that received candidate therapeutics were included in this report to determine whether the behavioral assays were capable of detecting changes in function over a wide range of outcomes.

RESULTS:

The behavioral assays are shown to be sensitive to detecting a wide range of motor functional outcomes after cervical hemisection in the nonhuman primate. Population curves on recovery of function were similar across the different tasks; in general, the population recovers to about 50% of baseline performance on measures of forelimb function.

CONCLUSIONS:

The behavioral outcome measures that the authors developed in this preclinical nonhuman primate model of SCI can detect a broad range of motor recovery. A set of behavioral assays is an essential component of a model that will be used to test efficacies of translational candidate therapies for SCI.

PMID:
22331214
PMCID:
PMC3468651
DOI:
10.1177/1545968311421934
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center