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Genes Dev. 2012 Jan 1;26(1):6-10. doi: 10.1101/gad.184416.111.

The enemy within: intronic miR-26b represses its host gene, ctdsp2, to regulate neurogenesis.

Author information

1
Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA.

Abstract

Differentiation of multipotent stem cells occurs through the highly coordinated control of gene expression. Repressor element 1 (RE1) silencing transcription factor (REST), a master transcriptional regulator in neuronal stem cells, restricts neuronal gene expression. REST activity is context-dependent and is modified by its cofactors, such as Ctdsp2. In this issue of Genes & Development, Dill and colleagues (pp. 25-30) report on the microRNA-mediated regulation of neural differentiation. Interestingly, this microRNA is post-transcriptionally regulated and modulates expression of its host gene, ctdsp2.

PMID:
22215805
PMCID:
PMC3258967
DOI:
10.1101/gad.184416.111
[Indexed for MEDLINE]
Free PMC Article

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